The Los Angeles Lakers have won four straight, but the San Antonio Spurs will look to snap that streak when they visit Crypto.com Arena tonight.
With key players missing, Los Angeles’ luck is bound to run out, and my Spurs vs. Lakers predictions are bullish on San Antonio at even-money odds.
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Here are my best NBA picks for Wednesday, November 5.
Tip-off is set for 10:00 p.m. ET, with the game airing on ESPN.
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Spurs vs Lakers prediction
Spurs vs Lakers best bet: Spurs moneyline (+100)
Although the Los Angeles Lakers are 6-2 on the season, their last four wins came against teams with a combined record of 15-14.
The San Antonio Spurs rank ninth in offensive rating (117), second in defensive rating (108.2), and fourth in net rating (8.8). They have allowed the fewest points per game this season, and San Antonio’s lockdown defense should be able to contain a Lakers team that will be without Austin Reaves (groin) tonight.
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I’ll back a Spurs team that’s hungry to get back in the win column after suffering its first loss of the season against Phoenix.
Spurs vs Lakers same-game parlay
Victor Wembanyama is off to a monstrous start to the season, averaging 43.6 PRA. He’s hit the Over in three of six matchups, though he posted an uncharacteristically low 20 PRA in Sunday’s loss to Phoenix. Expect a bounce-back performance tonight.
Led by Wemby, the Spurs boast one of the top defenses in the Association. The Lakers have no answers for him in the paint, and unless LA suddenly decides to start unleashing threes, it will be tough for the Lakers to put points on the board.
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Spurs vs Lakers SGP (+575)
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Victor Wembanyama Over 44.5 points + rebounds + assists
Our “from downtown” SGP: Dishing Dimes
With Reaves sidelined, Luka Doncic will have the ball in his hands more than usual.
Throughout his career, Doncic has averaged 9.5 assists against the Spurs, his highest average against any team.
Over the last three games, the Spurs have allowed the fourth-most assists to opponents.
Spurs vs Lakers SGP (+1600)
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Victor Wembanyama Over 44.5 points + rebounds + assists
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Luka Doncic Over 9.5 assists
Spurs vs Lakers odds
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Spread: San Antonio +2.5 (-115) | Los Angeles -2.5 (-105)
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Moneyline: San Antonio +115 | Los Angeles -135
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Over/Under: Over 230.5 (-110) | Under 230.5 (-110)
Spurs vs Lakers betting trend to know
San Antonio has cashed the moneyline in seven of its last nine games (+12.75 Units / 73% ROI). Find more NBA betting trends for Spurs vs. Lakers.
How to watch Spurs vs Lakers
Location
Crypto.com Arena, Los Angeles, CA
Date
Wednesday, November 5, 2025
Tip-off
10:00 p.m. ET
TV
ESPN
Spurs vs Lakers latest injuries
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