The San Francisco Giants (45-41) and the Arizona Diamondbacks (43-42) play the third game of a 4-game series Wednesday. First pitch from Chase Field in Phoenix is scheduled for 9:40 p.m. ET. Let’s analyze BetMGM Sportsbook’s MLB odds around the Giants vs. Diamondbacks odds and make our expert MLB picks and predictions for the best bets.
Season series: Diamondbacks lead 4-1
After winning the Monday opener 4-2 as +128 home underdogs, the Diamondbacks beat the Giants 8-2 as -120 favorites Tuesday — and we cashed on the moneyline and the total in the second game of the series. The Under (8.5) hit in the opener, while the Over (9.5) cashed the following night. RF Jake McCarthy hit a go-ahead 3-run shot in the fourth inning Tuesday, and LF Lourdes Gurriel Jr. added a 2-run homer in the fifth. Arizona has won back-to-back games following a 4-game skid from June 25-29.
Giants SS Willy Adames hit his 10th homer of the season Tuesday — a solo shot in the second — becoming the fourth San Francisco player to reach double-digit home runs. The Giants have lost 4 straight on the road and 7 of 8 games overall.
Giants at Diamondbacks projected starters
RHP Landen Roupp vs. RHP Merrill Kelly
Roupp (6-5, 3.43 ERA) makes his 17th start. He has a 1.44 WHIP, 3.8 BB/9 and 8.2 K/9 through 81 1/3 innings.
- Last start: Win, 5 1/3 IP, 0 ER (1 R), 7 H, 2 BB, 4 K in 3-1 victory at Chicago White Sox Friday
- 2025 road stats: 4-4, 4.56 ERA (47 1/3 IP, 24 ER), 1.59 WHIP, 9.3 K/9 in 10 starts
- Career vs. Diamondbacks: 0-0, 4.76 ERA (5 2/3 IP, 3 ER), 1.41 WHIP, 5 H, 3 BB, 6 K in 2 relief appearances, both in 2024
Kelly (7-4, 3.49 ERA) makes his 18th start. He has a 1.07 WHIP, 2.4 BB/9 and 9.2 K/9 through 98 innings.
- Last start: Loss, 5 IP, 3 ER (5 R), 6 H, 1 BB, 7 K in 9-8 home setback vs. Miami Marlins Friday
- 2025 home stats: 3-3, 3.31 ERA (51 2/3 IP, 19 ER), 1.08 WHIP, 9.2 K/9 in 9 starts
- 2025 vs. Giants: 1 road start (May 12), win, 7 IP, 1 ER, 8 H, 0 BB, 8 K in 2-1 victory
- Career vs. Giants: 8-5, 3.18 ERA (121 2/3 IP, 43 ER), 1.16 WHIP, 7.6 K/9 in 20 starts
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Giants at Diamondbacks odds
Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 12:21 p.m. ET.
- Moneyline (ML): Giants +120 (bet $100 to win $120) | Diamondbacks -145 (bet $145 to win $100)
- Run line (RL)/Against the spread (ATS): Giants +1.5 (-175) | Diamondbacks -1.5 (+145)
- Over/Under (O/U): 8.5 (O: -110 | U: -110)
Giants at Diamondbacks picks and predictions
Prediction
Diamondbacks 4, Giants 3
ARIZONA (-145) has outscored San Francisco 12-4 over the first 2 games of the series, rebounding from a 4-game losing streak.
Meanwhile, the Giants have dropped 7 of their last 8 games and have been held to 2 runs or fewer in each of their last 4 contests. Roupp has struggled on the road in his second season, posting a 4.56 ERA across 10 away starts.
BET DIAMONDBACKS (-145).
Arizona -1.5 (+145) is a risky play, even though the Diamondbacks have covered the run line in the first 2 games of the series. While they appear to be finding their form, they entered this set on a 4-game skid.
On the other side, San Francisco +1.5 (-175) is too steep a price for a team that has dropped 3 straight games by multiple runs.
PASS on the run line.
San Francisco has been held to 3 or fewer runs in 5 straight games, going 4-1 to the Under during that stretch.
The concern, however, is that Arizona may do the bulk of the scoring itself, having plated 7 or more runs in 3 of its last 5 games — a span in which the Over has hit 4 times. The lean is to the Under, with the expectation that Arizona’s offense regresses after an 8-run outburst Tuesday, but it’s not strong enough to warrant an official play.
LEAN UNDER 8.5 (-110).
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